Car T Therapy Side Effects

The side effects you may have and how serious they are will depend on how healthy you are before treatment your type of cancer how advanced it is the type of t cell transfer therapy you are receiving and the dose.

Car t therapy side effects. Severe muscle or joint pain shortness of breath low blood pressure and fast heart rate. What are the side effects of car t cell therapy. The most common side effects seen are. Detailed studies of two potential side effects of an emerging cancer immunotherapy could eventually help make this strategy car t cell therapy safer for patients.

T cell transfer therapy can cause side effects which people experience in different ways. Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer. Felipe samaniego m d shares what to know. Car t cells are made by extracting thousands of a patient s t cells sending them to a lab where they re outfitted with genes and proteins that improve their cancer fighting prowess and then re infusing them into the patient.

Instead car t cell therapy can lead to a short lived but severe reaction called cytokine release syndrome. Car t cell therapy side effects. The studies examined cytokine release syndrome and neurologic toxicities. These patients have run out of treatment options.

A remodeled car t cell therapy causes fewer neurologic side effects and is equally effective as the original form of the therapy according to results from the first clinical trial of the treatment in patients with b cell lymphomas. Ironically some of the adverse events are due to cytokine release that occurs because the patient is having a positive response to therapy. However side effects of car t cell therapy can be daunting. Car t cell therapy is a type of immunotherapy that s offering hope to some non hodgkin lymphoma patients but the side effects are different from those of other cancer treatments.

These include neurotoxicity which can result in headache confusion and. Risks and side effects. You won t have hair loss that commonly follows chemotherapy. Severe nausea vomiting diarrhea.

As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood. Serious side effects of this release can include very high fevers. Cytokine release syndrome which is similar to flu like symptoms headache. The car t cell targets the cd19 antigen on cancer cells.